Genomic analysis of hypoxia inducible factor alpha in ray-finned fishes reveals missing Ohnologs and evidence of widespread positive selection

Fishes are increasingly challenged by low dissolved oxygen in nature and their survival relies, in part, upon their molecular responses. This study sheds new light on the evolution and diversity of the hypoxia inducible factor, the master regulator of oxygen-dependent gene expression, in fishes.
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Dec 28, 2022