Omomyc is finally in the clinic. What a journey!
MYC is the most deregulated oncogene in human cancer, where it directs transcriptional programs that allow cancer cells to thrive and survive therapies. Despite being a most wanted target in cancer treatment, it has been long considered undruggable.
A new electrolyte formulation for safe and long-cycling batteries
Safety is an essential dimension of battery sustainability. Here we show an formulated electrolyte with excellent chemical and thermal stability proves nonflammable and works in a wide working temperature range from −75 to 80 °C.
Amazing! The classical optical neural network exhibits “quantum speedup”
Optical neural networks (ONNs) have drawn much attention in recent years. In order to further enhance the computational power of ONNs, optical correlation is introduced to ONNs and a new type of optical convolutional neural network is proposed which can show "quantum speedup".
A new low-latitude loess record unveils the rainfall cycle of the East Asian summer monsoon
A low-latitude loess profile from China revealed the dominant ~20,000-year cycle in rainfall change in the core zone of the East Asian summer monsoon, driven by variation in insolation controlled by precession, and precipitation and temperature variation may not follow the same orbital-scale cycles.
Train Horns Save Hundreds of Lives, Yet Kill Thousands from Noise Exposure
Fatalities at railroad crossings decreased by several hundred (2007-2022), attributable in part to Federally-mandated train horns at crossings. Yet sleep disturbance from railway noise contributes significantly to the burden of disease, causal to thousands of disability-adjusted life years (DALY).