Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
This study presents an optimized proteogenomic workflow for the discovery of neoantigens (in particular RNA-derived neoantigens) in a pan-cancer cohort and sheds light on the entity-agnostic prevalence of HLA-I peptide presentation of RNA processing events for tumor targeting.
One step closer to an Implantable Artificial Kidney
Our team at The Kidney Project chose a biohybrid approach to tissue engineering a universal donor kidney that mimics the tandem filtration-concentration physiology of a healthy kidney. Here, we show that cellular scaffolds can double as immunological barriers between host and allogeneic cells.
Revealing the contrasting roles of soil moisture−atmosphere feedbacks in modulating the abrupt transition from drought to pluvial conditions
There is a significant increase in the occurrence of drought and pluvial transitions globally during 1980−2020. We find that the transitive causal chains induced by land−atmosphere feedbacks play an important role in triggering the occurrence of drought and pluvial transitions.
Pacific Decadal Oscillation causes fewer near-equatorial cyclones in the north Indian Ocean
Our study finds a remarkable 43% decline in the frequency of low-latitude cyclones (LLCs, originating between 5°N and 11°N) during the post-monsoon season in the north Indian Ocean (NIO) in recent decades (1981-2010) compared to earlier decades (1951-1980).
