I joined the Chicago faculty in November 1997 in the Department of Ecology and Evolution and the College, after postdoctoral researches at Harvard with Walter Gilbert and Richard Lewontin. I received Ph.D. in December 1992 at the University of California at Davis in the laboratory of Charles Langley. A serendipitous finding of jingwei in African Drosophila, the first new gene ever known that was generated by retroposition and exon shuffling, in my doctoral research ignited my passion in a new and big problem: how does a new gene originate and evolve? I have been working on this problem since my years at Davis and found more and more interesting and challenging with the new gene problem. After years indulged in the rates, patterns and mechanisms of new gene evolution, I am attracted to the phenotypic evolution and expression network evolution driven by new genes. I am examining the evolutionary forces underlying new gene evolution and related phenotypic evolution, including evolutionary force 1 -- the natural selection for adaptation and evolutionary force 2 -- the sexual selection for reproductive success, proposed by Charles Darwin, and other forces such as the neutrality and the conflict in evolution of genes and genomes.